Title: International Research Consortium on Dengue Risk Assessment, Management and Surveillance
Grant agreement number: 281803
EC contribution: 5.999.213 €
Duration: 66 months Starting date: 01/09/2011
Funding scheme: Collaborative Project (small‐ or medium‐scale focused research project) for specific international cooperation actions (SICA)
Dengue is an emerging disease of major global significance and represents an enormous burden for health care systems in endemic countries. Differentiating dengue from other common febrile illnesses before complications develop is difficult - simple and inxpensive strategies are urgently needed to support early and accurate diagnosis, as well as to identify patients at high risk of developing complications, in order both to improve case management and to facilitate appropriate use of limited resources. Evaluation of early clinical features alongside readily available laboratory tests in a large cohort of patients encompassing the breadth of dengue disease encountered in endemic settings is necessary to develop a robust case definiton for dengue, and could also prove to be very useful for the development of prognostic algorithms. Early detecion of outbreaks, with improved surveillance systems and a prompt response to imminent outbreaks, could prove highly effective in reducing the numbers of dengue cases globally. In combination with identification of areas likely to be at risk of dengue outbreaks, as defined by risk mapping, such strategies could bring great health benefits by preventing outbreaks and reducing numbers of cases, with consequent reductions in overall morbidity and mortality from dengue.
These four work packages are supported by a fifth work package dedicated to networking and translational activities to ensure that outputs from the various research activities are used to maximal advantage. Finally a sixth work package will focus on administrative issues, ensuring that reports, financial statements etc. are prepared and submitted in time. The structure of the 6 work packages is illustrated below.
● University of Carabobo, Valencia, Venezuela
● Oswaldo Cruz Foundation, Recife, Brazil
● International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b)
● Universidad Autonoma De Yucatan (UADY)